The allyl rearrangement reaction is a common type of reaction in the fields of pharmaceutical and fine chemical industry. There are two problems in the allyl rearrangement process in the traditional process. First, the reaction is carried out in kettle reactor, and the mass transfer is slow, so the reaction needs to be conducted at ultra-low temperature, and the energy consumption is high. The second problem is the large consumption of acid and solvent in the reaction process. The raw material consumption is also large, and the burden of subsequent processing is increased.

Himile Chemical verified the continuous flow microchannel reactor with the synthesis reaction of vitamin A. The following table shows the laboratory data of allyl rearrangement reaction using reactor and continuous flow microchannel reactor: