Grignard reaction is a very important reaction type in organic synthesis, and has a wide range of application. Since the reaction is intensely exothermic, it has strict requirements on the temperature and feed rate. If the cooling facilities were damaged or the feeding was too fast, the generated heat would not be able to transferred in time and the production process would get out of control, causing fire, explosion and other consequences.

Himile Chemical used the lab-scale microchannel reactor to carry out the Grignard reaction. By using the extremely strong mass transfer and heat transfer performance of the microreactor, the reaction time can be shortened and the reaction heat can be removed in time to improve the reaction safety.

The data resulted from conventional tank reactors and microchannel reactors are listed in the table below: