Esterification is a common type of reaction in organic synthesis. It is commonly used in the synthesis of fine chemical intermediates and has extensive application value in the field of fine chemicals. The esterification reaction is a reversible reaction, the reaction rate is slow, and the amount of heat is large. In the production process, precise control of the reaction conditions is required. In the conventional production process, heat cannot be removed in time, leading to uncontrolled and causing safety problems. The use of Tangential flow reactor can enhance mass transfer and heat transfer, provide precise control of reaction conditions, avoid back mixing, and increase production efficiency and safety.